Explain why Adrenaline is used in Anaphylactic Shock. Anaphylaxis is a severe form of life threateing allergic reaction that causes swelling of mouth and tongue, breathing problems, flushing, collapse and a loss of consciousness. Adrenaline is used as a treatment for anaphylaxis.
Adrenaline is the life saving drug for the treatment of anaphylactic shock. Adrenaline 0.3 – 0.5 ml of 1:1000 solution (1 mg/ml) is administered intramuscularly.
◙ Causative agents of Anaphylactic Shock : Anaphylaxis or anaphylactic shock can be triggered by these agents peanuts, shellfish, and insect bites or stings. These can cause severe anaphylactic reaction or allergic reaction lead to anaphylactic shock.
◙ Symptoms of Anaphylaxis :
►Vasodilation → Peripheral Resistance↓ → BP↓
►Hypotension – BP ↓
►Increased vascular permeability↑
►Activation of vagal pathways
◙ Mechanism of Action:
Adrenaline produces the following effect :
►ß1- medicated cardiac stimulation → HR↑ + FOC↑
►α1 – mediated vasoconstriction → Peripheral Resistance↑ →BP↑
►α1 – mediated vasoconstriction → Mucosal Oedema ↓
►ß2 stimulation → Bronchodilation + ↓Release of mediators from Mast cells
►Physiologic Antagonist of Histamine → ↓Release of mediators from Mast cells
That explains Why Adrenaline is used in Anaphylactic Shock.
◙ Uses of Adrenaline as Treatment of Anaphylactic Shock:
A patient with a history of allergic attack should be considered for Adrenaline. This is available in the market as a auto-injector or pen. Administration of adrenaline on certain attack will eliminate the chances of death.
|Type of medicine||Sympathomimetic|
|Used for||Anaphylactic Shock|
|Medicine Name||Emerade®; EpiPen®; Jext®|
|Available as||Auto-injection device or ‘pen’|
Questions Type : Explain Why
Chapter : Autonomic Nervous System
Explain Why Adrenaline is used in Anaphylactic Shock.